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Insidermedicine In Depth - May 31, 2010 - Depression Meds and Miscarriage Risk

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Taking antidepressants while pregnant may increase the risk of miscarriage, according to research published in the latest issue of the Canadian Medical Association Journal. Here is some information about the use of antidepressants during pregnancy: • Untreated depression during pregnancy can be harmful to both mother and fetus • Antidepressants have not been proven to be 100% safe during pregnancy, although the risk of them causing problems appears to be low • The decision to use antidepressants during pregnancy is a decision that needs to be made on an individual basis for each woman with her health care provider Researchers from the University of Montreal studied over 5,000 women who had experienced a miscarriage. The investigators compared the antidepressant use of each woman who miscarried with that of 10 pregnant women who did not have a miscarriage at or before the same point in their pregnancy. Overall, 5.5% of the women who miscarried filled at least one prescription for antidepressants during their pregnancy, compared with only 2.7% of the comparison group of women. The use of one antidepressant during pregnancy was associated with a 68% increased risk for miscarriage, while using two or more of these drugs was associated with an increased risk of more than three times. Antidepressants most closely linked with miscarriage were paroxetine, commonly known as Paxil, venlafaxine, commonly known as Effexor, as well as antidepressants belonging to drug classes known as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). We had a chance to speak to Dr. Anick Bérard, one of the investigator's of this study, who offered some further insight. Today's research suggests that women taking antidepressants who are pregnant or trying to become pregnant should discuss the benefits and risks of taking this medication while pregnant. Never make any changes to you medication without first discussing it with your physician.
Категория: Наука и техника
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