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Vivelle-Dot or Estradiol Medication Information (dosing, side effects, patient counseling)

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Vivelle-Dot is also known by the generic name: Estradiol. Vivelle-DOT comes in 0.025mg, 0.0375mg, 0.05mg, 0.075mg, and 0.1mg per 24 hours transdermal patches. Vivelle-DOT is most commonly used for the purpose of adding estrogen to the body when the ovaries have been taken out or do not work properly and also to prevent or lower the signs of menopause. It may be given to you for other reasons, talk with your doctor or pharmacist. No matter what your doctor has you taking Vivelle-DOT for it, this patch should be applied to clean, dry skin below the waistline two times weekly. Change the location of the patch when applying a new one and only wear one patch at a time. If you miss a dose of Vivelle-DOT: • Put on a missed patch as soon as you think about it after taking of the old one The best way to store Vivelle-DOT: • Store at room temperature. • Store in a dry place. Do not store in a bathroom or refrigerator • After you take off a skin patch, be sure to fold the sticky sides of the patch to each other. • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. • Check with your pharmacist about how to throw out unused drugs. Usual doses of Vivelle-DOT range from 0.025mg/24 hours to 0.1mg/24 hours. Some common side effects with Vivelle-DOT include headache, pain, depression, anxiety, dizziness, and breast tenderness. Do not use Vivelle-DOT patches if: • You have or have a history of deep vein thrombosis or pulmonary embolism • You have a history of a stroke or heart attack • You are pregnant • You have breast cancer Vivelle-DOT patches come with the US Black Box warnings of: • Endometrial cancer o There is an increased risk of developing endometrial cancer if a woman who has a uterus uses Vivelle-DOT patches • Cardiovascular disease o Estrogen therapy, such as Vivelle-DOT patches, should not be used alone for the prevention of cardiovascular disease in postmenopausal women. If used alone, it can lead to increased risk of stroke and deep vein thrombosis (DVT). • Breast cancer o There is an increased risk of breast cancer when using estrogen plus progestin therapy. • Dementia o There is an increased risk of developing dementia if taking estrogen therapy alone in post-menopausal women. When using Vivelle-DOT patches, remember it is important to tell your doctor pharmacist if you have: • Signs of an allergic reaction, like rash; hives; itching; blistered, or peeling skin with or without fever • Chest pain or pressure • Shortness of breath • Coughing up blood • Very bad headache • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, or blurred eyesight • Back pain • A lump in the breast, breast soreness • Breast pain • Very bad skin reaction
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