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Acetaminophen (Tylenol) Metabolism and Toxicity
 
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Please watch: "LEARN HEART SOUNDS IN 20 MINUTES!!!" https://www.youtube.com/watch?v=NrdZhCXtc7Q -~-~~-~~~-~~-~- This is the best online medical lectures site, providing high quality medical and nursing lectures for students across the globe. Our lectures are oversimplified for adequate learning, less memorization and proper understanding of difficult concept in clinical medicine.
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Acetaminophen overdose
 
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Tim Vo, MD Denver Health Residency in Emergency Medicine University of Colorado SOM, Dept. of Emergency Medicine This video is for educational purposes only and does not constitute medical advice.
Просмотров: 21581 Timothy Vo
Acetaminophen Toxicity / Poisoning
 
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Acetaminophen Toxicity / Poisoning Instructional Tutorial Video CanadaQBank.com QBanks for AMC Exams, MCCEE, MCCQE & USMLE
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Metabolism of Acetaminophen (paracetamol)
 
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This video explains: - Acetaminophen metabolism -Therapy of acetaminophen overdose
Просмотров: 16077 BioMed GP
How is acetaminophen metabolized?
 
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A 2-minute review of all you need to know about acetaminophen metabolism
Просмотров: 214 The Dentist!
Ibuprofen vs. Acetaminophen: What’s The Difference?
 
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Many forms of medicine offer relief from pain, but what’s the difference between them? Read More: Nociceptors: the sensors of the pain pathway http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964977/ “Pain, as a submodality of somatic sensation, has been defined as a ‘complex constellation of unpleasant sensory, emotional and cognitive experiences provoked by real or perceived tissue damage and manifested by certain autonomic, psychological, and behavioral reactions.’” Ibuprofen: Uses, Interactions and Side Effects http://www.medicalnewstoday.com/articles/161071.php “Ibuprofen blocks the production of prostaglandins, substances our body releases in response to illness and injury.” ____________________ DNews is dedicated to satisfying your curiosity and to bringing you mind-bending stories & perspectives you won't find anywhere else! New videos twice daily. Watch More DNews on TestTube http://testtube.com/dnews Subscribe now! http://www.youtube.com/subscription_center?add_user=dnewschannel DNews on Twitter http://twitter.com/dnews Trace Dominguez on Twitter https://twitter.com/tracedominguez Julia Wilde on Twitter https://twitter.com/julia_sci DNews on Facebook https://facebook.com/DiscoveryNews DNews on Google+ http://gplus.to/dnews Discovery News http://discoverynews.com Download the TestTube App: http://testu.be/1ndmmMq
Просмотров: 247648 Seeker
How does your body process medicine? - Céline Valéry
 
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View full lesson: http://ed.ted.com/lessons/how-does-your-body-process-medicine-celine-valery Have you ever wondered what happens to a painkiller, like ibuprofen, after you swallow it? Medicine that slides down your throat can help treat a headache, a sore back, or a throbbing sprained ankle. But how does it get where it needs to go in the first place? Céline Valéry explains how your body processes medicine. Lesson by Céline Valéry, animation by Daniel Gray.
Просмотров: 1081408 TED-Ed
Tylenol can lead to liver failure, death
 
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One of the most popular over-the-counter painkillers, acetaminophen (the active ingredient in Tylenol), could kill you. It is considered to be safe when taken at recommended doses, but taking even two extra pills a day could put your liver and your life at risk, according to a new, in-depth ProPublica report. Acetaminophen overdose now sends over 78,000 people to the emergency room each year, and the drug is now considered the leading cause of acute liver failure in the country. RT's Ameera David has more information on the hidden dangers of what is believed to be a harmless drug. Find RT America in your area: http://rt.com/where-to-watch/ Or watch us online: http://rt.com/on-air/rt-america-air/ Like us on Facebook http://www.facebook.com/RTAmerica Follow us on Twitter http://twitter.com/RT_America
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Drug Metabolism Made Simple *ANIMATED*
 
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metabolism is the protective biochemical process by which our bodies alter xenobiotics either enzymatically or nonenzymatically. generally, drug metabolism begins with hydrophobic drug and converts it to a more hydrophilic metabolite to facilitate its elimination. an understanding of the drug metabolism process and the potential outcomes is critical for developing safe and useful pharmaceuticals. drug metabolism can result in one of two products, an inactive metabolite and an active metabolite. inactive metabolites of the drugs basically have no pharmacological activity of the original drug. an example of that would be the hydrolysis of procaine into para aminobenzoic acid and diethylethanolamine which results in the loss of the anesthetic activity of procaine. on the other hand, an active metabolite can mean that a metabolite can retain the same activity of the parent drug, that's apparent when codeine is demthylated to a more active drug which is morphine. however, in some cases we notice a result known as bioactivation where the parent drug is inactive and the metabolite would have a pharmacological activity, in this case the inactive parent drug is called a prodrug. an example of a prodrug is enalapril which has no activity as an antihypertensive, but upon hydrolysis it becomes enalaprilat which is a potent antihypertensive drug. bioactivation of a drug can also lead to toxic metabolites, the widely used acetaminophen has a metabolite that is called n-acetyl-p-benzoquinone imine which is hepatoxic, I explained the mechanism of the toxicity and the antidote in my previous video which I linked in the description below. The liver has the highest concentration of drug-metabolizing enzymes, because of it’s location between the gastrointestinal tract and the systemic circulation. Based on the reactions involved in the metabolism process we can classify the metabolic pathways into phase I metabolism and phase II. Phase I metabolism is characterized as a functionalization reaction, where they add or reveal a functional group by oxidation, reduction, or hydrolysis, hence, leading to increase in overall polarity of the drug which facilitates its excretion in the urine Oxidation is the most common phase I reaction, Cytochrome p450 is a superfamily of oxidases that are responsible for the majority of oxidation reactions, it’s found in very high concentrations in the liver. Oxidation can also happen through alcohol dehydrogenase which is an enzyme that oxidizes alcohols into aldehydes from primary alcohols and to ketones from secondary. Aldehydes can be oxidized from to carboxylic acid by the enzyme aldehyde dehydrogenase. We can see that in the example of the conversion of acetaldehyde to acetic acid in the metabolism of ethanol. Another phase I reaction is the reduction reaction, there are several reductase enzymes common reduction reactions include the reduction of disulfide bonds, in which the disulfides would be reduced to free sulfhydryls. Another reduction reaction is done by the aldo-keto reductases which reduce carbonyl containing compounds back to alcohol in a process opposite to the oxidation done by alcohol dehydrogenase. The last type of phase I metabolism reaction is hydrolysis, hydrolysis is basically the addition of water across a bond resulting in a more water-soluble metabolite. A great example of hydrolysis is ester hydrolysis which is performed by the enzyme esterase found throughout the body, esterase is responsible for the hydrolysis of an ester into a more soluble alcohol or carboxylic acid. Phase II Phase II reactions are commonly called conjugation reaction owing to the fact they add a functional group on the drug for the purpose of increasing its polarity. The conjugation process requires an enzyme generally termed as transferase, that transfers the large polar molecule called a co-factor onto the drug, Examples of phase II reactions: glucuronidation is the most common phase II reaction, glucuronosyltransferase is the enzyme that uses UDP-GA as the cofactor to transfer glucuronic acid to several functional groups like hydroxyl groups, carboxylic acid ,and hydroxylamines. The glucuronic acid adds a significant amount of hydrophilicity to the molecules facilitating it’s excretion process. Another popular reaction is glutathione conjugation which results from the addition of glutathione molecule to an electrophilic substrate. Being a nucleophile glutathione generally acts to detoxify electrophiles. Glutathione-s-transferase is the enzyme responsible for the reaction of glutathione with electrophiles like epoxides and halides. After the conjugation, the product is excreted as mercapturic acid in the urine. Paracetamol antidote video: https://www.youtube.com/watch?v=hg_gpWjWsRM
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Does Acetaminophen Cause Liver Damage?
 
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The FDA is worried that many people are overdosing on the popular painkiller.
Просмотров: 9220 ABC News
Is Tylenol safe with alcohol?
 
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http://www.iHealthTube.com Pharmacist Sue Brenan answers common health questions.
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Liver Health: 4 Worst Damaging Habits- Thomas DeLauer
 
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Liver Health: 4 Worst Damaging Habits- Thomas DeLauer… http://www.ThomasDeLauer.com for all your business, health, and fitness answers. The number one over the counter medication responsible for wrecking our livers is acetaminophen. Join Celebrity Trainer, Author & Organic Foods Expert, Thomas DeLauer to find out what other habits may be contributing to the health and function of our livers. Learn how the liver plays a big role in our metabolism, how we burn fat, how we get into shape, and detoxification. 1) Too much self-medication: One of the main functions of the liver is to break down substances that we take by mouth, including medications, herbs and supplements. This process usually takes place efficiently and without causing any harm. When new medications are developed, they are extensively tested to make sure they are safe before being approved for general use. Acetaminophen, when used as directed, is extremely safe even for people with liver disease. However, taking too much acetaminophen at once, or taking a high dose of acetaminophen continuously over several days can cause damage to the liver. How it Damages the Liver: A dose of Tylenol is absorbed by the gastrointestinal system and released into the bloodstream, where it alleviates pain and symptoms of fever. The liver filters the blood, which is responsible for metabolizing Tylenol into compounds that can be excreted by the body. About 90% is metabolized into harmless substances and excreted in the urine by the kidneys. Another 2% is removed without being metabolized. Between 5-10% is metabolized into a toxic compound called N-acetyl-p-benzoquinoeimine (NAPQI). Normally, the liver can safely remove NAPQI by combining it with gluthathione and converting it into a water-soluble product that is excreted in bile. However, after an overdose, the liver does not have enough gluthathione to combine with the NAPQI. Excess amounts of the toxic chemical cause rapid cell death, necrosis, tissue damage, and potentially deadly acute liver failure. (1,2,3) 2) Alcohol abuse: The liver can only handle a certain amount of alcohol at any given time, so if you drink more than the liver can deal with by drinking too quickly, or drinking too much, your liver cells struggle to process it. When alcohol reaches the liver, it produces a toxic enzyme called acetaldehyde, which can damage liver cells and cause permanent scarring. 3) Smoking: Though cigarette smoke does not directly come into contact with the liver, it does indirectly affect the liver. The chemicals in cigarette smoke eventually make their way to the liver. These chemicals cause oxidative stress on the liver, which leads to damage to the liver cells and fibrosis. Oxidative stress is involved in the aging of all the organs of the body. Oxidation produces free radicals that damage the cells of the body. 4) Lack of Sleep: If you want to keep your body — and particularly your liver ­– in good condition, it is important that you get enough sleep. During sleep, the body repairs and renews its cells, so lack of sleep will interfere with that. In turn, if the liver cannot repair and renew itself as you sleep, it can’t function properly when you’re awake. A study published in the Journal of Anatomy found that sleep deprivation can cause oxidative stress to the liver. It was found that livers weren’t processing fat efficiently and instead allowed fat to accumulate (which proves that the body cannot function well without a properly working liver) (8) References: 1) Acetaminophen and Liver Injury: Q & A for Consumers. (n.d.). Retrieved from http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm168830.htm 2) How Does Tylenol Cause Liver Damage? (n.d.). Retrieved from https://www.schmidtlaw.com/how-does-tylenol-cause-liver-damage/ 3) How Does Tylenol Cause Liver Damage? (n.d.). Retrieved from https://www.schmidtlaw.com/how-does-tylenol-cause-liver-damage/ 4) Maher, J. (1997). Exploring Alcohol’s Effects on Liver Function. Retrieved from https://pubs.niaaa.nih.gov/publications/arh21-1/05.pdf 5) Alcohol — Love Your Liver. (n.d.). Retrieved from http://loveyourliver.com.au/alcohol/ 6) Heavy smoking and liver. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088100/ 7) 5 Common Habits That Damage Your Liver. (n.d.). Retrieved from http://www.healthyandnaturalworld.com/common-habits-that-damage-your-liver/ 8) Sleep deprivation predisposes liver to oxidative stress and phospholipid damage: a quantitative molecular imaging study. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408992/ 9) Liver Health: The Role of Turmeric in Fatty Liver Disease. (n.d.). Retrieved from http://www.globalhealingcenter.com/natural-health/turmeric-and-fatty-liver-disease/ 10) Turmeric Can Reduce Risk of Fatty Liver Disease. (n.d.). Retrieved from https://hepfree.nyc/turmeric-can-reduc-e/
Просмотров: 242214 Thomas DeLauer
Signs That You May Have Acetaminophen Liver Damage
 
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Signs That You May Have Acetaminophen Liver Damage - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - More Home Remedies Videos : Top 10 Foods for Diabetes Control - https://www.youtube.com/watch?v=644xAnXyBaQ Just Add 1 Teaspoon of This Mixture to Your Morning Coffee to Boost Weight Loss - https://www.youtube.com/watch?v=xHTv4XKkIRI AFTER SEEING THIS YOU WILL WANT TO SLEEP WITH A ONION ON YOUR FEET - https://www.youtube.com/watch?v=lNfOz7Pp-Nw Salt, Pepper and Lemon Can Solve These 9 Problems Better Than Any Medicine - https://www.youtube.com/watch?v=quAOm_U4T-I Doctors Are Amazed A Recipe That Makes Bones, Knees And Joints Stronger ! - https://www.youtube.com/watch?v=L0RhBkhz1vo They Say Drinking Lemon Water In The Morning Is Good For You Here's What They Didn't Tell You - https://www.youtube.com/watch?v=vRyy9q_cpMA Start Eating This If You Have Thin Brittle Nails, Insomnia Or Hair Loss - https://www.youtube.com/watch?v=iheJnfiuXhI This Green Juice Hydrates Brain and Cures Migraines - https://www.youtube.com/watch?v=4PueZ81OQS4 DON'T SPEND ANY MORE MONEY ON MEDICINES FOR HIGH CHOLESTEROL OR HIGH BLOOD PRESSURE - https://www.youtube.com/watch?v=b-17p9i3q3M 3 Amazing Drinks to Flush Your Body Clean of Toxins and Purify Your Blood - https://www.youtube.com/watch?v=vGDsOr36MGo Say Goodbye to Diabetes Forever Without Any Medications and Any Special Effort - Recipe - https://www.youtube.com/watch?v=rzyXeokF-58 The Best Artery Cleaning Foods - 10 of Them That Also Keep You Safe from Heart Attacks - https://www.youtube.com/watch?v=LlvdBzv-Gdc THIN TO THICK HAIR MAGIC, GROW YOUR HAIR FAST OVERNIGHT WITH 1 INGREDIENT - https://www.youtube.com/watch?v=Nt_pSSN57Mk HOW TO CLEAN THE FEET WITH BAKING SODA - https://www.youtube.com/watch?v=2UG_jMnrvEQ What Will Happen After Eating 3 Eggs Daily You Will Be Surprised - https://www.youtube.com/watch?v=1eN_K0F-YSU 1 Pinch Of This Magical Ingredient In Lemon Water Will Vanish Your Migraines And Headaches - https://www.youtube.com/watch?v=iFbaH7sjSbU These Facial Masks Can Remove Wrinkles, Acne Scars and Stains After the 2nd Use - https://www.youtube.com/watch?v=pVWvAdcr9vE 6 Convincing Reasons You Should Start Using Eggshells In Your Garden - https://www.youtube.com/watch?v=Eyff19lHTsY This Is What Really Happens When You Crack Your Knuckles - https://www.youtube.com/watch?v=Z1LcxddWK3I 10 Signs You’re Not Drinking Enough Water - https://www.youtube.com/watch?v=V_wmClNfzdM IF YOUR KIDNEY IS IN DANGER, THE BODY WILL GIVE YOU THESE 6 SIGNS! - https://www.youtube.com/watch?v=yNKgnelzWHU HERE’S WHAT HAPPENS IF YOU PUT GARLIC IN YOUR EAR! - https://www.youtube.com/watch?v=Lt3gbeIw5DU If You Eat 2 Bananas Per Day for a Month, This Is What Happens to Your Body - https://www.youtube.com/watch?v=_QsnUaK3Nus 7 Foods You Should Avoid That Cause Inflammation - https://www.youtube.com/watch?v=byJ2gtyL0HE SPEED UP YOUR METABOLISM, REMOVE TOXINS AND LOSE WEIGHT AT ONCE IN ONLY 72 HOURS - https://www.youtube.com/watch?v=cSwhsT862mg If You See This Label On The Fruit Do Not Buy It At Any Cost - This is Why - https://www.youtube.com/watch?v=FlSAl03GYSo Top 10 Bad Habits That Damage Your Hair - https://www.youtube.com/watch?v=ry7m89mAAik GOODBYE CHOLESTEROL, BLOOD GLUCOSE, LIPIDS AND TRIGLYCERIDES - https://www.youtube.com/watch?v=jxxl9uDjNuA IF YOU SUFFER FROM DIABETES, HAIR LOSS, HEART AND JOINT INFLAMMATION TRY THIS POWERFUL FRUIT - https://www.youtube.com/watch?v=-US9pbUIROc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - ➜ Please Share This With Your Friends And Family. ➜ Subscribe : https://goo.gl/8qbbjV ➜ Facebook : https://www.facebook.com/EverydaySimpleHealthTips/ ➜ YouTube : https://www.youtube.com/c/EverydaySimpleHealthTips ➜ twitter : https://twitter.com/HealthTipssssss ➜ Google Plus : https://plus.google.com/u/0/+EverydaySimpleHealthTips ➜ Blogspot : http://everydaysimplehealthtips.blogspot.com
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First Pass Metabolism - Pharmacology Lect 6
 
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First Pass Metabolism: Definition and core concepts. Learn pharmacology with my other videos below: (1) Pharmacokinetics & ADME: http://youtu.be/CMRZqdrkCZw DRUG ABSORPTION Videos: (2) Drug Absorption Overview: http://youtu.be/eya9jR3v7i8 (3) Bioavailability: http://youtu.be/rv2Rpdi7OHM DRUG DISTRIBUTION Videos: (4) Drug Distribution Overview: http://youtu.be/DH2WGUd7MBs (5) Volume of Distribution: http://youtu.be/B63sqUfvFQQ ------------------ DRUG METABOLISM Videos: (6) First Pass Metabolism: http://youtu.be/5AB8WkCbz4k (7) Phase I Metabolism: http://youtu.be/GGLddVpVg9M (8) Phase II Metabolism: http://youtu.be/iIWAUo05GFE (9) First Order and Zero Order Kinetics: http://youtu.be/XEotDfKhNTw (10) Drug Half-life: http://youtu.be/eTqPsqnbwoc (11) First-order elimination rate constant and half-life-details: http://youtu.be/De9999Jj-5Q ------------------------------------------ DRUG ELIMINATION / EXCRETION (12) Drug Clearance: http://youtu.be/csywV3MYHDg (13) Renal Excretion of Drugs: http://youtu.be/8c3gqI6R-Vw (14) Ion Trapping: [not yet posted] (15) Dosage Regimens: [not yet posted] --------------------------------------------------------------------- Factors That Affect Drug Metabolism: (16) Enzyme Induction: http://youtu.be/Dtbkc8F_ff0 (17) Competitive Inhibition Overview: http://youtu.be/iNIxMuHuL3w (18) Competitive Inhibition of Statins: http://youtu.be/Lt1-mjMFniE (19) Acetaminophen toxicity (Clinical Correlate): [Not yet posted] (20) Pharmacogenomics Overview: http://youtu.be/3vZxbX5P9TU (21) Slow Acetylators - Pharmacogenomics: [not yet posted] Help us caption & translate this video! http://amara.org/v/BZ0q/
Просмотров: 229686 Areo Saffarzadeh
Acetaminophen (Paracetamol) Overdose – Emergency Medicine | Lecturio
 
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This video “Acetaminophen (Paracetamol) Overdose” is part of the Lecturio course “Emergency Medicine” ► WATCH the complete course on http://lectur.io/paracetamoloverdose ► LEARN ABOUT: - Acetaminophen (Paracetamol) Overdose - Mechanism and clinical effects - When to give NAC - Essential principles of managing poisonings ► THE PROF: As an assistant professor of emergency medicine at the Johns Hopkins University School of Medicine, Julianna Jung, M.D. is an expert in teaching students. She has been the director of medical student education in the Emergency Medicine department since 2006 and was appointed the associate director of the Johns Hopkins Medicine Simulation Center in 2011. She is also a national leader in education, holding a position on the Executive Committee of Clerkship Directors in Emergency Medicine. ► LECTURIO is your single-point resource for medical school: Study for your classes, USMLE Step 1, USMLE Step 2, MCAT or MBBS with video lectures by world-class professors, recall & USMLE-style questions and textbook articles. Create your free account now: http://lectur.io/paracetamoloverdose ► INSTALL our free Lecturio app iTunes Store: https://app.adjust.com/z21zrf Play Store: https://app.adjust.com/b01fak ► READ TEXTBOOK ARTICLES related to this video: Drug Intoxications — Symptoms and Treatment http://lectur.io/paracetamoloverdosearticle ► SUBSCRIBE to our YouTube channel: http://lectur.io/subscribe ► WATCH MORE ON YOUTUBE: http://lectur.io/playlists ► LET’S CONNECT: • Facebook: https://www.facebook.com/lecturio.medical.education.videos • Instagram: https://www.instagram.com/lecturio_medical_videos • Twitter: https://twitter.com/LecturioMed
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FDA warns of acetaminophen liver damage
 
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The Food and Drug Administration is asking doctors to stop prescribing acetaminophen that has more than 325mg per dose.
Просмотров: 6679 CNN
Acetaminophen Nursing Considerations, Side Effects and Mechanism of Action Pharmacology for Nurses
 
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Grab our free cheatsheet covering the 50 most commonly prescribed medications right here: https://www.NRSNG.com/50meds Listen to all the episodes at: https://www.nrsng.com/medmaster-podcast/ View full post: https://www.nrsng.com/acetaminophen-tylenol/ Acetaminophen Generic Name: acetaminophen Trade Name: Tylenol Indication: pain, fever Action: inhibit the synthesis of prostaglandins which play a role in transmission of pain signals and fever response Therapeutic Class: antipyretic, non-opioid analgesic Nursing Considerations  do not exceed 4g of acetaminophen per day to limit risk for liver, renal, and cardiac damage  overdose will lead to hepatotoxicity  Acetadote is the antidote for overdose  may increase risk for bleed with warfarin therapy  may alter blood glucose measurements
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Toxic Effects of Ethanol on Liver Metabolism | Alcohol Toxicity | Metabolic Consequences
 
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Video lesson on the negative effects of ethanol on liver metabolism. Alcohol abuse can lead to toxic outcomes on the metabolism of the liver, including dysregulation of glycolysis, lactic acidosis, TCA cycle dysfunction, hypoglycemia, and hyperlipidemia, leading to fatty liver disease (hepatosteatosis). This lesson will explain why and how these toxic outcomes occur. Hey everyone, in this lesson you will learn what the consequences of ethanol consumption and metabolism are on the functioning of important metabolic pathways in the liver. You will learn the step-by-step pathway by which alcohol metabolism and its metabolites alters metabolism and function of glycolysis, TCA cycle, gluconeogenesis, and fatty acid synthesis and oxidation. I hope you all find this video helpful! If you do, please like and subscribe for more videos like this one :) ---------------------------------------------------------------------------------------------------- For books and other supplemental information on these topics, please check out my Amazon Affiliate Page ➜ https://www.amazon.com/shop/jjmedicine Support future lessons and lectures ➜ https://www.patreon.com/jjmedicine Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine
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Tylenol and Hangovers: A Dangerous Mix?
 
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Acetaminophen -- the active ingredient in Tylenol -- is bad news for your liver if you take too much of it. The same is true for alcohol. So should you avoid popping Tylenol to take the edge off the morning-after hangover? Probably yes -- although the biology behind how the two substances interact is more complex than you might imagine. UPDATED VERSION! (Previous version contained a frustrating error - for which we apologize profusely!) FURTHER RESOURCES Medline Plus: Trusted Health Information for You. Acetaminophen. U.S. National Library of Medicine, National Institute of Health. AHFS Consumer Medication Information. Revised: 15 August 2013. Accessed online: 27 September 2013. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a681004.html FDA information on acetaminophen toxicity: http://www.fda.gov/Drugs/DrugSafety/SafeUseInitiative/ucm230396.htm Mayo Clinic: Acetaminophen and Children: Why Dose Matters: http://www.mayoclinic.com/health/acetaminophen/HO00002 Pro Publica report on acetaminophen risks: http://www.propublica.org/article/tylenol-mcneil-fda-use-only-as-directed L.E. Schmidt, K Dalhoff, H.E. Poulson. Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity. Hepatology (32) 2002; p.876-882. http://www.ncbi.nlm.nih.gov/pubmed/11915034 F. Yang, D. A. Beard. Thermodynamically based profiling of drug metabolism and drug-drug metabolic interactions: A case study of acetaminophen and ethanol toxic interactions. Biophysical Chemistry, 120 (2) p. 121-134. 20 March 2006. Accessed online: 27 September 2013. http://dx.doi.org/10.1016/j.bpc.2005.10.013 P. Zhao, T.K. Kalhourn, J.T. Slattery. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rats. Hepatology (36); p. 326-335. 2002. K. Thummel, et al. Ethanol and production of hepatotoxic metabolite of acetaminophen in healthy adults. Clinical Pharmacology and Therapeutics (2000) 67; p. 591-599. http://dx.doi.org/10.1067/mcp.2000.106574 THIS WEEK'S RISK BITES TEAM: Producer: Andrew Maynard Research Director: David Faulkner Background Research: Alyssa berry Risk Bites is your guide to making sense of risk. We cover everything from understanding and balancing the risks and benefits of everyday products, to health science more broadly, to the potential impacts of emerging technologies, to making sense of risk perception. If you enjoy our videos, please subscribe, and spread the word!
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Acetaminophen (paracetamol) pharmacology
 
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Use the PharmacoPhoto video 'flash-card' series to reinforce your knowledge of drug classes and specific medications.
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How Dangerous is Acetaminophen (Tylenol)?
 
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This six minute video is full of great information and stories about the dangers of Acetaminophen. Tylenol is the leading cause of of liver failure in the US
Просмотров: 50852 PainKiller Awareness
Doctors Warn About Dosage Dangers
 
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An OU student died on Feb. 25 due to an overdose of acetaminophen.
Просмотров: 2608 KOCO 5 News
The Dangers of Tylenol
 
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Using the common pain reliever acetaminophen can lead to liver failure. Dr. Pyrsopolous talks about the dangers of Tylenol.
Просмотров: 4125 FLHospitalOrlando
Metabolism Of Paracetamol
 
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Screencast for Metabolism Of Paracetamol
Просмотров: 1000 Leonard Leging
Acetaminophen Toxicity
 
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Просмотров: 7462 mymedplanet
OU Student Dies After Tylenol Overdose
 
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A University of Oklahoma student died of liver failure after an overdose of Tylenol, which she was taking for tooth pain.
Просмотров: 13674 KOCO 5 News
Paracetamol toxicity - Biochemical Basis - Lecture
 
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“Acetaminophen (Paracetamol) is metabolised predominantly by a phase II reaction to innocuous sulfate and glucuronide metabolites; however, a small proportion of acetaminophen is metabolized by a phase I reaction to a hepatotoxic metabolite formed from the parent compound by the cytochrome P450 CYP2E1. This metabolite, N-acetyl-p-benzoquinoneimine (NAPQI), is detoxified by binding to “hepatoprotective” glutathione to become harmless, water-soluble mercapturic acid, which undergoes renal excretion.” N-acetyl-p-benzoquinone imine (NAPQI) depletes the glutathione levels. N-acetyl cysteine replenish the glutathione levels. (Ref. Harrison 19th Ed., p. 2027)
Просмотров: 1680 Karthikeyan Pethusamy
Tylenol Liver Damage (Acetaminophen)
 
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http://www.injurylawyersus.com If you or a loved one have liver damage or liver failure, and you suspect that Tylenol is the cause, we want to hear from you. Tylenol (Acetaminophen) is one of the most widely used over-the-counter drugs in the country, but it has been known to cause liver damage. In fact, the FDA has mandated that a "black box" warning of liver risk be placed on all products containing acetaminophen.
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NSAIDs & Acetaminophen - Learn with Visual Mnemonics
 
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Visual Learner Studios uses visual mnemonics to teach pharmacology fast and efficiently. Website: http://VisualLearner.net/ Facebook: http://www.facebook.com/visuallearnerstudios Twitter: https://twitter.com/VL_Studios NSAIDs are a class of drugs that has analgesic, antipyretic and anti-inflammatory properties. They work by inhibiting the enzyme Cyclooxygenase, which is responsible for catalyzing the formation of prostaglandins and thromboxane from arachidonic acid. Prostaglandins have a wide range of functions within the body including the regulation of inflammation. Therefore, by stopping the synthesis of prostaglandins, an overall anti-inflammatory effect occurs COX has two main isoenzymes, COX-1 and COX-2. COX-1 has a role in many physiological processes, one of which is protecting the stomach mucosa from the acidic environment. COX-2, on the other hand, mainly functions in inflammation. Therefore, the wanted effects of NSAIDs are actually from inhibiting COX-2 specifically. Most NSAIDs are non-selective COX inhibitors, meaning that they inhibit both COX 1 and 2. As a result, prostaglandin levels in the stomach can be reduced and the risk of stomach or duodenum ulceration increases. Selective COX-2 inhibitors were developed to avoid this problem, but in practice they are usually used for different conditions and they present with their own set of adverse effects which we won’t delve into today. Make sure to subscribe to our Youtube channel, like us on Facebook and follow us on Twitter for all the latest updates! Happy Studying!
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'Miracle' Girl Survives Tylenol Overdose
 
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Family starts prayer chain to Saint Benedicta to nurse toddler back to health.
Просмотров: 12058 ABC News
Overdosing on pain reliever acetaminophen
 
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A new report from ProPublica finds acetaminophen may have caused more than 1,500 deaths over 10 years. More from CNN at http://www.cnn.com/
Просмотров: 41082 CNN
APAP Metabolism part 1
 
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Overview of the pathways for acetaminophen metabolism. The 3 major pathways are sulfation, glucuronidation, and formation of the iminoquinone via CYP450 in the liver. Also explains why too much APAP can cause liver toxicity.
Просмотров: 3269 Mike De Guia
Acetaminophen Toxicity: The Pharmacist's Role in Prevention and Treatment
 
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To receive credit, visit: http://www.freece.com/FreeCE/CECatalog_Details.aspx?ID=04f74287-80ff-414d-9ba7-7cc267b5e166 Program Overview Acetaminophen toxicity is the leading cause of acute liver failure in the United States. The misuse of this common analgesic causes 56,000 emergency department visits, 26,000 hospital admissions, and 500 deaths each year. Pharmacists can play a vital role in preventing toxicity by educating patients about the safe use of acetaminophen.As members of the health care team, pharmacists should be knowledgeable of the indications and proper administration of acetylcysteine for the management of acetaminophen-induced hepatotoxicity. Pharmacist Educational Objectives - Describe reasons why acetaminophen overdoses occur -Discuss the clinical presentation and treatment of acetaminophen overdoses -List steps taken by the FDA and the pharmaceutical industry to prevent acetaminophen toxicity -Identify strategies that pharmacists can apply to prevent acetaminophen overdoses Accreditation Pharmacist 0798-0000-13-130-H05-P Disclaimer: The Content and Program Materials contained are provided by FreeCE/PharmCon as a service to its registrants and to the public. THE INFORMATION OFFERED IS FOR GENERAL EDUCATIONAL AND INFORMATIONAL PURPOSES ONLY. THIS IS NOT INTENDED TO PROVIDE INFORMATION OR ADVICE CONCERNING SPECIFIC PROBLEMS OF SITUATIONS. IT IS NOT INTENDED AS A SUBSTITUTE FOR THE PROFESSIONALS OWN RESEARCH, OR FOR HIS OWN PROFESSIONAL JUDGMENT OR ADVICE FOR A SPECIFIC PROBLEM OF SITUATION. NEITHER FREECE/PHARMCON NOR ANY CONTENT PROVIDER INTENDS TO OR SHOULD BE CONSIDERED TO BE RENDERING MEDICAL, PHARMACEUTICAL OR OTHER PROFESSIONAL ADVICE. WHILE FREECE/PHARMCON AND ITS CONTENT PROVIDERS HAVE EXERCISED CARE IN PROVIDING INFORMATION, NO GUARANTEE OF ITS ACCURACY, TIMELINESS OR APPLICABILITY CAN BE OR IS MADE. YOU ASSUME ALL RISKS AND RESPONSIBILITIES WITH RESPECT TO ANY DECISIONS OR ADVICE MADE OR GIVEN AS A RESULT OF THE USE OF THE PROGRAM, PROGRAM MATERIALS, FREECE WEBSITE OR INTERACTION WITH CONTENT PROVIDERS. IF MEDICAL OR OTHER EXPERT ASSISTANCE IS REQUIRED, YOU SHOULD OBTAIN THE SERVICES OF A COMPETENT PROFESSIONAL.
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Acetaminophen toxicity
 
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Просмотров: 155 Dr. Nini Iyizoba
Acetaminophen Toxicity
 
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An overview of acetaminophen toxicity, assessment, treatment, phases of presentation and the Rumack Matthew nomogram.
Просмотров: 11959 TheAncientScholar
Tylenol Overdose Tease
 
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Просмотров: 177 WIFR TV
FUNNY Acetaminophen (Tylenol) CAUTION / Equate Brand (Walmart)
 
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Equate branded acetaminophen (Tylenol) from Walmart has a big caution, warning, be advised notice you need to see. EQUATE BRAND: http://amzn.to/2oRaeqq
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Tylenol overdose
 
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Tylenol overdose
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Codeine: What You Need To Know
 
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Codeine is an opioid found naturally in Papaver somniferum, the opium poppy. It's somewhat misleading to call it an opioid since codeine primarily functions as a prodrug, offering little of its own activity. Morphine seems to be its primary active metabolite. The drug is typically a controlled substance, yet it may also be available over-the-counter (OTC) in certain combinations. Its name comes from the Greek word "kodeia," which means "poppy head." Medically, codeine is used as an analgesic, antitussive, and antidiarrheal. It's also taken recreationally, often at higher doses. TDC overview page (with references): https://thedrugclassroom.com/video/codeine/ Reddit discussion: https://www.reddit.com/r/TheDrugClassroom/comments/6xmsro/codeine_what_you_need_to_know/ Codeine = Methylmorphine; 3-methylmorphine ------------ Donate to The Drug Classroom: https://www.patreon.com/TheDrugClassroom https://www.paypal.me/TheDrugClassroom Bitcoin: 1HsjCYpBHKcVCaW4uKBraCGkc1LK8xoj1B ------------ Thank you to my Patreon supporters: Glen Marshall, Laura Cornwell, RollSafe.org, Jonathon Dunn, Thomas Anaya, Ross Martin, Star Ape, michael hoogwater, Beau Jaco, Alexander Pavlenko, Lars Nilsson, Billy, Abdulaziz Al-Kuwari, Sam A., Reece hosford, Felix Wisniewski, Jarrod o'connell, Daniel X Moore, Robert Jarman, Dahmon Bicheno, Christoffer Finstad, Zachary Thomas Binkley, Sami Parsegov, Dane Overman, Squadra Dumay, Dragonhax, Case van der Burg, Alexander Norsk, and David Kernell. ------------ Facebook - http://facebook.com/thedrugclassroom Twitter - http://twitter.com/drugclassroom Email - seth@thedrugclassroom.com ------------ The Drug Classroom (TDC) is dedicated to providing the type of drug education everyone should have. Drugs are never going to leave our society and there has never been a society free from drugs. Therefore, it only makes sense to provide real education free from propaganda. TDC doesn't advocate drug use. Rather, we operate with the intention of reducing the harm some substances can bring. Feel free to ask questions!
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tylenol overdose
 
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Kelsey Wolff and Becky Pion (special appearance by Madison)
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Acetaminophen Poisoning
 
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Taking Acetaminophen Safely
 
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FDA's new video, "Taking Acetaminophen Safely" is the latest installment of the Medicines in My Home series. It provides background about acetaminophen, a common over-the-counter pain reliever and fever reducer, and the many different types of medications that might contain acetaminophen; the danger of taking more acetaminophen than directed; how to learn if acetaminophen is in a medicine by looking at the Drug Facts label; and how to take acetaminophen safely. It also encourages consumers to contact their healthcare professionals if they have questions or concerns.
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FDA: Don't Overdo It with Acetaminophen
 
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Acetaminophen is generally safe at recommended doses, but if you take more than that, even just a little more, it can cause serious, even fatal liver damage. In fact, acetaminophen poisoning is a leading cause of liver failure in this country.
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MOAs of Acetaminophen & NSAIDs | TYLENOL® Professional
 
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Scientific animation demonstrating the clinical implications of the Mechanisms of Action (MOAs) of acetaminophen (TYLENOL®) and NSAIDs. Commentary explores how to counsel patients on their selection and use of OTC analgesics in pain management. For more information, visit TylenolProfessional.com. This video is intended for U.S. healthcare professionals only.
Просмотров: 11480 TYLENOLOFFICIAL
Tylenol (Acetaminophen) Liver Failure
 
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http://www.tylenol-lawsuit-lawyers.com. Free Legal Consultation 1-800-930-8090.Tylenol (Acetaminophen) toxicity is a leading cause of acute liver failure, resulting in an estimated 400 deaths in this country each year. Many of these events are happening because patients are unknowingly taking too much of the drug. Serious liver damage and even death can result.
Просмотров: 726 druglawsuits
Why Tylenol Became Popular in the U.S.
 
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Please subscribe! https://goo.gl/XV4H04 New Videos Every Other Week! The story of how Tylenol convinced the world it was more than just acetaminophen and better than aspirin. For more information on the subject of Acetaminophen and the history of Tylenol I recommended: Nancy West Communications: http://goo.gl/AY9xDx & Pro Publica's Report: https://goo.gl/KWKccL Follow Me: www.twitter.com/BostWiki Snapchat: thelatimes ------------------------------------------------------------------ The history of acetaminophen dates back to the latter part of the 19th century. The substance was first described in chemical literature in 1878. In 1886, Drs. Arnold Cahn and Paul Hepp of France were treating a patient suffering from intestinal parasites. They had been investigating naphthalene for its beneficial effect in the treatment of this problem. When their drug supply ran out, they ordered more from a local pharmacy. An inexperienced pharmacist mistakenly filled the prescription with acetanilide. The physicians found that acetanilide produced marked fever reduction in one of their patients who, along with intestinal parasites, had a febrile disease. As Drs. Cahn and Hepp continued to prescribe acetanilide, they also noticed its analgesic properties. It wasn't until 1899, however, that the relationship between acetaminophen and acetanilide was discovered by Karl Morner of Germany. He learned that acetanilide is metabolized in the body to become acetaminophen. Ten years later, another German physician, Joseph Freiher von Mering, first synthesized acetaminophen. Although his research confirmed that the drug was effective against pain and fever, von Mering recommended extensive investigation into all analgesics and antipyretics. Acetaminophen was not prescribed nor studied any further until 1949 when research on chemically related drugs revived interest in the compound. Modern research techniques and clinical use in England confirmed the effectiveness and safety of acetaminophen as a fever and pain reliever. In the late 1940s, McNeil Laboratories, as the company was then known, had defined as a new product objective an analgesic which would be different, available for marketing and prescription only. At about the same time, James Roth, M.D., a University of Pennsylvania Graduate School of Medicine gastroenterologist, was lecturing throughout the United States about the dangers of aspirin. Subsequently, he began advocating for APAP. Dr. Roth became a pr In the spring of 1955, McNeil introduced TYLENOL Elixir for Children, the company's first single ingredient acetaminophen product. The outstanding success of TYLENOL was attributed to a unique marketing strategy:
Просмотров: 11110 BostWiki
Acetaminophen (Tylenol) Overdose in Children
 
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Commercial project for NURS 313.
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tylenol overdose
 
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Acetaminophen Overdoses can be Fatal!
 
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Especially during flu season, beware of accidental acetaminophen poisoning. For more information visit: http://www.conqueringarthritis.com/arthritisarticles.htm Barbara's Book: http://ConqueringArthritis.com/book
Просмотров: 3545 Barbara Allan