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Dorrough Explains Different Levels of Lean & Dangers
 
08:50
http://www.vladtv.com/ - Ice Cream Paint Job" rapper Dorrough explains the different levels of lean, revealing that there are different stages of potency, with the strongest being "muddy," which Dorrough says will physically effect you in the biggest way. Dorrough also speaks about new music he's working on, including a mixtape with French Montana & DJ Smallz and possibly a new project with DJ Drama.
Просмотров: 666358 djvlad
First Taste - Mucinex Fast-Max liquid medicine
 
05:13
First taste - Mucinex fast - max cold, flu and sore throat medicine follow me - youtube.com/thesammabe twitter.com/sammabe Check out my favorite youtubers David Banther - youtube.com/dlb1752 David DiFranco - youtube.com/thecreativeone BF vs GF - youtube.com/bfvsgf Judy/Benji - youtube.com/itsjudyslife Alisha's DIY - youtube.com/alishasdiy
Просмотров: 14178 S M
#39 Biochemistry Nucleotide Metabolism I Lecture for Kevin Ahern's BB 451/551
 
49:34
1. Contact me at kgahern@davincipress.com / Friend me on Facebook (kevin.g.ahern) 2. Download my free biochemistry book at http://biochem.science.oregonstate.edu/biochemistry-free-and-easy 3. Take my free iTunes U course at https://itunes.apple.com/us/course/biochemistry/id556410409 4. Check out my free book for pre-meds at http://biochem.science.oregonstate.edu/biochemistry-free-and-easy 5. Course video channel at http://www.youtube.com/user/oharow/videos?view=1 6. Check out all of my free workshops at http://www.youtube.com/playlist?list=PLlnFrNM93wqyTiCLZKehU1Tp8rNmnOWYB&feature=view_all 7. Check out my Metabolic Melodies at http://www.davincipress.com/metabmelodies.html 8. Take my courses for credit (wherever you live) via OSU's ecampus. For details, see http://ecampus.oregonstate.edu/soc/ecatalog/ecourselist.htm?termcode=all&subject=BB 9. Course materials at http://oregonstate.edu/instruct/bb451 Nucleotide Metabolism 1. Nucleotides consist of a) sugar, b) nitrogenous base, and c) phosphate 2. Nucleosides consist of a a) sugar and b) nitrogenous base 3. The sugars of nucleosides and nucleotides are either ribose (found in ribonucleotides of RNA) or deoxyribose (found in deoxyribonucleotides of DNA). 4. Unless otherwise specified, the term "nucleoside" will be used in this class to indicate either ribonucleosides (contain ribose) or deoxyribonucleosides (contain deoxyribose). 5. The term nucleoside phosphate is equivalent to a nucleotide (nucleoside + phosphate + base = nucleotide). This is true whether it is a monophosphate, diphosphate, or triphosphate. 6. The nitrogenous bases found in nucleotides include adenine (purine), guanine (purine), thymine (pyrimidine), cytosine (pyrimidine), and uracil (pyrimidine). 7. The bases adenine, guanine, and cytosine are found in both ribonucleotides and deoxyribonucleotides. Thymine is almost always found in deoxyribonucleotides. Uracil is found primarily in ribonucleotides and rarely in DNA, but does appear as a deoxyribonucleotide intermediate in thymidine metabolism. 8. Ribonucleotides are the building blocks of RNA and deoxyribonucleotides are the building blocks of DNA. 9. Nucleotides and nucleosides are made in cells by 1) salvage pathways or 2) de novo pathways. 10. In salvage pathways, nucleic acids can be broken down to nucleoside monophosphates or individual bases. Monophosphates be rephosphorylated to triphosphates. Alternatively, nucleoside monophosphates can lose a phosphate (becoming nucleosides) or can lose the phosphate and the sugar to become a base. 11. In de novo synthesis of nucleotides, ribonucleotides are synthesized first. Deoxyribonucleotides are made from ribonucleoside diphosphates. Atoms in the ring of pyrimidines come from aspartate and carbamoyl phosphate. 12. The enzyme carbamoyl phosphate synthetase has a catalytic strategy involving channeling of the substrates through the enzyme as catalysis occurs. This is important because some of the intermediates (such as carboxyphosphate and carbamic acid) are very unstable in aqueous solution. 13. The most important regulatory enzyme for the pathway of pyrimidine biosynthesis is ATCase, which plays an important role in balancing the amounts of purines and pyrimidines. The enzyme catalyzes the linkage of aspartate to carbamoyl phosphate. 14. The first pyrimidine nucleotide made in the de novo pyrimidine pathway is UMP. 15. UMP is phosphorylated to UDP (by uridine monophosphate kinase) and then to UTP (by nucleoside diphosphokinase = NDPK) before conversion to CTP. Each nucleoside monophosphate has a specific kinase to convert it to the diphosphate. 16. Conversion of UTP to CTP is catalyzed by the enzyme CTP synthase and it is inhibited by CTP. 17. The most important regulatory enzyme for the first part of purine biosynthesis is PRPP amidotransferase. It is inhibited fully by AMP and GMP, but is only partly inhibited (is still partly active) when only one of these molecules is present. 18. In the process of making IMP, fumarate is released, thereby connecting purine biosynthesis to the citric acid cycle. 19. The first purine-like intermediate in de novo purine biosynthesis is inosinic acid (or IMP), which has the purine-like base hypoxanthine linked to ribose (and ribose is linked to phosphate). 20. IMP can be converted to AMP or GMP. The pathway by which IMP leads to GMP is inhibited by GMP and uses energy from ATP, whereas the pathway where IMP is converted to AMP is inhibited by AMP and uses energy from GTP. 21. The pathway to GMP involves oxidation, whereas the pathway that leads to AMP uses aspartic acid to donate an amine and fumarate is again released. 22. Nucleoside monophosphates from de novo synthesis can be converted by kinases to nucleoside diphosphates and nucleoside triphosphates. Nucleoside diphosphate kinase (NDP kinase or NDPK) converts all nucleoside diphosphates to nucleoside triphosphates.
Просмотров: 13479 Kevin Ahern
Hip and Knee Arthritis On Demand Seminar
 
01:00:04
Learn more about our Orthopedics services: http://coordinatedhealth.com/services/orthopedics/ Get to know Dr. Williams: http://coordinatedhealth.com/team/john-williams-md/ More info: http://coordinatedhealth.com/video/hip-and-knee-arthritis-on-demand-seminar/ Dr. John Williams and Coordinated Health present Hip and Knee Arthritis On Demand Seminar, discussing surgical and non-surgical treatment options for the arthritis of the hip and knee.
Просмотров: 755 Coordinated Health
[04/18/12] Everyone shh I have a headache ok?
 
04:12
shh go away
Просмотров: 78 PocketsOfYourPants
Migraine | Relief | (616)608-3606 | Grand Rapids | MI | Headache Migraine
 
03:29
Migraine | Relief | (616)608-3606 | Grand Rapids | MI | Headache Migraine http://www.ClearConnectionsChiropractic.com Hello and welcome to an episode of the Clear Connection and I'm your host, Dr. Krystal. Today we're going to cover a topic that affects many people...Migraines! If you suffer from migraine headaches, you're not alone, currently 30 million people in the United States suffer from migraines and as many as 50% of migraine sufferers remain undiagnosed. So let's go over the basics... So what classifies a migraine? It's not just a bad headache, but an intense, throbbing pain usually in one or both temples. Some people also become nauseated and sensitive to light and sound. Other symptoms can include vomiting and diarrhea. A typical attack can last between 4-72 hours, occur without warning, and may be accompanied by an aura, which causes changes in your vision. Migraines occur when swollen blood vessels in the brain press on nearby nerves causing pain, which classifies them as vascular-type headaches. This dilation, or opening up, of the blood vessels activates your sympathetic NS which is the part of your NS that controls stress and pain, also known as your "fight or flight" response. Migraines are usually set off by various triggers. Alcohol, stress, certain odors, loud noises, bright lights, and certain foods are some of the common triggers, but not the only things that may spark a migraine. If you're prone to migraines you may want to avoid foods such as: chocolate, red wine, aged cheeses, and processed or fermented foods --especially those containing MSG. Migraines are also associated with hormonal changes, which is why a woman often experiences this type of headache during her menstrual cycle or with the use of birth control pills. By their early 20s, women are 3 times more likely to have migraines than men. There is no specific cure for migraine headaches, but the goal is to prevent symptoms by avoiding triggers and learning the different options for how to best eliminate the issue. Common treatment involves taking certain medications to reduce the occurrence and intensity of symptoms, but be aware that taking medicines more than 3 days a week may lead to rebound headaches, taking too much acetaminophen can damage your liver, and too much ibuprofen or aspirin can irritate your stomach. Another more natural and less invasive option would be to visit a chiropractor! Chiropractic focuses on the overall function of your body by assessing if there is interference within your nervous system, the master controller of your cells, tissues, organs, and bodily functions. Most often with migraine sufferers, a chiropractor will pay special attention to the upper bones of the neck to make certain they are in proper alignment, not causing pressure on the spinal cord or the nerves that supply the head and neck. When these upper bones are adjusted back into their normal alignment, many of the issues associated with migraines get resolved. The focus of chiropractic care is to rid the body of nerve interference so it can work properly and get to the underlying cause of the problem and not just fix the symptoms. Support Groups American Council for Headache Education - www.achenet.org The National Migraine Association - www.migraines.org National Headache Foundation - www.headaches.org Clear Connections Chiropractic 1500 East Beltline Avenue Southeast #145 Grand Rapids, MI 49506 (616) 608-3606 http://www.clearconnectionschiropractic.com Serving: 49506, 49503, 49507, 49501, 49502, 49510, 49514, 49516, 49518, 49523, 49530, 49555, 49560, 49588, 49515, 49505, 49599, 49546, 49528, 49525, 49509, 49508, 49504, 49548, 49512, 49519, 49534, 49544, 49355, 49356, 49357, 49301 http://www.youtube.com/watch?v=9WjA0gQZVms
Просмотров: 566 Clear Connections Chiropractic
Subways Are for Sleeping / Only Johnny Knows / Colloquy 2: A Dissertation on Love
 
01:29:15
Subways Are for Sleeping is a musical with a book and lyrics by Betty Comden and Adolph Green and music by Jule Styne. The original Broadway production played in 1961-62. The musical was inspired by an article about subway homelessness in the March 1956 issue of Harper's and a subsequent 1957 book based on it, both by Edmund G. Love, who slept on subway trains throughout the 1950s and encountered many unique individuals. With the profits from his book, Love then embarked on a bizarre hobby: over the course of several years, he ate dinner at every restaurant listed in the Manhattan yellow pages directory, visiting them in alphabetical order. After two previews, the Broadway production, directed and choreographed by Michael Kidd, opened on December 27, 1961 at the St. James Theatre, where it ran for 205 performances. The cast included Orson Bean, Sydney Chaplin, Carol Lawrence, Gordon Connell, Grayson Hall, and Green's wife Phyllis Newman (whose costume, consisting solely of a towel, was probably Freddy Wittop's easiest design in his distinguished career), with newcomers Michael Bennett and Valerie Harper in the chorus. Subways Are for Sleeping opened to mostly negative reviews. The show already was hampered by a lack of publicity, since the New York City Transit Authority refused to post advertisements on the city's buses and in subway trains and stations for fear they would be perceived as officially sanctioning the right of vagrants to use these facilities as overnight accommodations. Producer David Merrick and press agent Harvey Sabinson decided to invite individuals with the same names as prominent theatre critics (such as Walter Kerr, Richard Watts, Jr. and Howard Taubman) to see the show and afterwards used their favorable comments in print ads. Thanks to photographs of the seven "critics" accompanying their blurbs (the well-known real Richard Watts was not African American), the ad was discovered to be a deception by a copy editor. It was pulled from most newspapers, but not before running in an early edition of the New York Herald Tribune. However, the clever publicity stunt allowed the musical to continue to run and it eventually turned a small profit. Newman won the Tony Award for Best Featured Actress in a Musical, and nominations went to Bean for Best Featured Actor and Kidd's choreography. http://en.wikipedia.org/wiki/Subways_Are_For_Sleeping
Просмотров: 465574 Remember This
Calling All Cars: Banker Bandit / The Honor Complex / Desertion Leads to Murder
 
01:28:09
The radio show Calling All Cars hired LAPD radio dispacher Jesse Rosenquist to be the voice of the dispatcher. Rosenquist was already famous because home radios could tune into early police radio frequencies. As the first police radio dispatcher presented to the public ear, his was the voice that actors went to when called upon for a radio dispatcher role. The iconic television series Dragnet, with LAPD Detective Joe Friday as the primary character, was the first major media representation of the department. Real LAPD operations inspired Jack Webb to create the series and close cooperation with department officers let him make it as realistic as possible, including authentic police equipment and sound recording on-site at the police station. Due to Dragnet's popularity, LAPD Chief Parker "became, after J. Edgar Hoover, the most well known and respected law enforcement official in the nation". In the 1960s, when the LAPD under Chief Thomas Reddin expanded its community relations division and began efforts to reach out to the African-American community, Dragnet followed suit with more emphasis on internal affairs and community policing than solving crimes, the show's previous mainstay. Several prominent representations of the LAPD and its officers in television and film include Adam-12, Blue Streak, Blue Thunder, Boomtown, The Closer, Colors, Crash, Columbo, Dark Blue, Die Hard, End of Watch, Heat, Hollywood Homicide, Hunter, Internal Affairs, Jackie Brown, L.A. Confidential, Lakeview Terrace, Law & Order: Los Angeles, Life, Numb3rs, The Shield, Southland, Speed, Street Kings, SWAT, Training Day and the Lethal Weapon, Rush Hour and Terminator film series. The LAPD is also featured in the video games Midnight Club II, Midnight Club: Los Angeles, L.A. Noire and Call of Juarez: The Cartel. The LAPD has also been the subject of numerous novels. Elizabeth Linington used the department as her backdrop in three different series written under three different names, perhaps the most popular being those novel featuring Det. Lt. Luis Mendoza, who was introduced in the Edgar-nominated Case Pending. Joseph Wambaugh, the son of a Pittsburgh policeman, spent fourteen years in the department, using his background to write novels with authentic fictional depictions of life in the LAPD. Wambaugh also created the Emmy-winning TV anthology series Police Story. Wambaugh was also a major influence on James Ellroy, who wrote several novels about the Department set during the 1940s and 1950s, the most famous of which are probably The Black Dahlia, fictionalizing the LAPD's most famous "cold case", and L.A. Confidential, which was made into a film of the same name. Both the novel and the film chronicled mass-murder and corruption inside and outside the force during the Parker era. Critic Roger Ebert indicates that the film's characters (from the 1950s) "represent the choices ahead for the LAPD": assisting Hollywood limelight, aggressive policing with relaxed ethics, and a "straight arrow" approach. http://en.wikipedia.org/wiki/LAPD
Просмотров: 59085 Remember This
Our Miss Brooks: Board of Education Day / Cure That Habit / Professorship at State University
 
01:29:12
Our Miss Brooks is an American situation comedy starring Eve Arden as a sardonic high school English teacher. It began as a radio show broadcast from 1948 to 1957. When the show was adapted to television (1952--56), it became one of the medium's earliest hits. In 1956, the sitcom was adapted for big screen in the film of the same name. Connie (Constance) Brooks (Eve Arden), an English teacher at fictional Madison High School. Osgood Conklin (Gale Gordon), blustery, gruff, crooked and unsympathetic Madison High principal, a near-constant pain to his faculty and students. (Conklin was played by Joseph Forte in the show's first episode; Gordon succeeded him for the rest of the series' run.) Occasionally Conklin would rig competitions at the school--such as that for prom queen--so that his daughter Harriet would win. Walter Denton (Richard Crenna, billed at the time as Dick Crenna), a Madison High student, well-intentioned and clumsy, with a nasally high, cracking voice, often driving Miss Brooks (his self-professed favorite teacher) to school in a broken-down jalopy. Miss Brooks' references to her own usually-in-the-shop car became one of the show's running gags. Philip Boynton (Jeff Chandler on radio, billed sometimes under his birth name Ira Grossel); Robert Rockwell on both radio and television), Madison High biology teacher, the shy and often clueless object of Miss Brooks' affections. Margaret Davis (Jane Morgan), Miss Brooks' absentminded landlady, whose two trademarks are a cat named Minerva, and a penchant for whipping up exotic and often inedible breakfasts. Harriet Conklin (Gloria McMillan), Madison High student and daughter of principal Conklin. A sometime love interest for Walter Denton, Harriet was honest and guileless with none of her father's malevolence and dishonesty. Stretch (Fabian) Snodgrass (Leonard Smith), dull-witted Madison High athletic star and Walter's best friend. Daisy Enright (Mary Jane Croft), Madison High English teacher, and a scheming professional and romantic rival to Miss Brooks. Jacques Monet (Gerald Mohr), a French teacher. Our Miss Brooks was a hit on radio from the outset; within eight months of its launch as a regular series, the show landed several honors, including four for Eve Arden, who won polls in four individual publications of the time. Arden had actually been the third choice to play the title role. Harry Ackerman, West Coast director of programming, wanted Shirley Booth for the part, but as he told historian Gerald Nachman many years later, he realized Booth was too focused on the underpaid downside of public school teaching at the time to have fun with the role. Lucille Ball was believed to have been the next choice, but she was already committed to My Favorite Husband and didn't audition. Chairman Bill Paley, who was friendly with Arden, persuaded her to audition for the part. With a slightly rewritten audition script--Osgood Conklin, for example, was originally written as a school board president but was now written as the incoming new Madison principal--Arden agreed to give the newly-revamped show a try. Produced by Larry Berns and written by director Al Lewis, Our Miss Brooks premiered on July 19, 1948. According to radio critic John Crosby, her lines were very "feline" in dialogue scenes with principal Conklin and would-be boyfriend Boynton, with sharp, witty comebacks. The interplay between the cast--blustery Conklin, nebbishy Denton, accommodating Harriet, absentminded Mrs. Davis, clueless Boynton, scheming Miss Enright--also received positive reviews. Arden won a radio listeners' poll by Radio Mirror magazine as the top ranking comedienne of 1948-49, receiving her award at the end of an Our Miss Brooks broadcast that March. "I'm certainly going to try in the coming months to merit the honor you've bestowed upon me, because I understand that if I win this two years in a row, I get to keep Mr. Boynton," she joked. But she was also a hit with the critics; a winter 1949 poll of newspaper and magazine radio editors taken by Motion Picture Daily named her the year's best radio comedienne. For its entire radio life, the show was sponsored by Colgate-Palmolive-Peet, promoting Palmolive soap, Lustre Creme shampoo and Toni hair care products. The radio series continued until 1957, a year after its television life ended. http://en.wikipedia.org/wiki/Our_Miss_Brooks
Просмотров: 33808 Remember This
The Great Gildersleeve: Anniversary Present / Gildy Almost Goes to Europe / Leroy Writes a Theme
 
01:29:30
Premiering on August 31, 1941, The Great Gildersleeve moved the title character from the McGees' Wistful Vista to Summerfield, where Gildersleeve now oversaw his late brother-in-law's estate and took on the rearing of his orphaned niece and nephew, Marjorie (originally played by Lurene Tuttle and followed by Louise Erickson and Mary Lee Robb) and Leroy Forester (Walter Tetley). The household also included a cook named Birdie. Curiously, while Gildersleeve had occasionally spoken of his (never-present) wife in some Fibber episodes, in his own series the character was a confirmed bachelor. In a striking forerunner to such later television hits as Bachelor Father and Family Affair, both of which are centered on well-to-do uncles taking in their deceased siblings' children, Gildersleeve was a bachelor raising two children while, at first, administering a girdle manufacturing company ("If you want a better corset, of course, it's a Gildersleeve") and then for the bulk of the show's run, serving as Summerfield's water commissioner, between time with the ladies and nights with the boys. The Great Gildersleeve may have been the first broadcast show to be centered on a single parent balancing child-rearing, work, and a social life, done with taste and genuine wit, often at the expense of Gildersleeve's now slightly understated pomposity. Many of the original episodes were co-written by John Whedon, father of Tom Whedon (who wrote The Golden Girls), and grandfather of Deadwood scripter Zack Whedon and Joss Whedon (creator of Buffy the Vampire Slayer, Firefly and Dr. Horrible's Sing-Along Blog). The key to the show was Peary, whose booming voice and facility with moans, groans, laughs, shudders and inflection was as close to body language and facial suggestion as a voice could get. Peary was so effective, and Gildersleeve became so familiar a character, that he was referenced and satirized periodically in other comedies and in a few cartoons. http://en.wikipedia.org/wiki/Great_Gildersleeve
Просмотров: 916 Remember This
SECSRT 045 He Had His Shirt Off And Is Pretty Ripped
 
01:14:28
On this week's episode of SEC Sports Roundtable, Shane Bailey is joined by Chad Caldwell to talk Vanderbilt Football and Cole Hodges to talk Ole Miss Football as they enter week 3 of 2-a-days. West End is ready to Anchor Down and Chad Caldwell brings us up to speed on the changes happening on campus, Vandy's uniforms, Why Franklin was the right hire and how Vanderbilt finally has some depth on its roster. Cole brings us up to speed with the Rebels as he talks about the shock of hiring Freeze, and how long it took to accept it. Cole also talks about the challenges of installing Freeze's high octane offense, and the academic influence he brings to the program. He also tells us how a fast start leads to a lot of losses. All this and more this week on episode 45 of the Roundtable. As requested a link tio theiTunes audio version of the podcast: http://itunes.apple.com/us/podcast/sec-sports-roundtable-podcast/id462503118?mt=2&ign-mpt=uo%3D4
Просмотров: 3208 Shane Bailey
The Great Gildersleeve: Gildy Drives a Mercedes / Gildy Is Fired / Mystery Baby
 
01:29:31
Premiering on August 31, 1941, The Great Gildersleeve moved the title character from the McGees' Wistful Vista to Summerfield, where Gildersleeve now oversaw his late brother-in-law's estate and took on the rearing of his orphaned niece and nephew, Marjorie (originally played by Lurene Tuttle and followed by Louise Erickson and Mary Lee Robb) and Leroy Forester (Walter Tetley). The household also included a cook named Birdie. Curiously, while Gildersleeve had occasionally spoken of his (never-present) wife in some Fibber episodes, in his own series the character was a confirmed bachelor. In a striking forerunner to such later television hits as Bachelor Father and Family Affair, both of which are centered on well-to-do uncles taking in their deceased siblings' children, Gildersleeve was a bachelor raising two children while, at first, administering a girdle manufacturing company ("If you want a better corset, of course, it's a Gildersleeve") and then for the bulk of the show's run, serving as Summerfield's water commissioner, between time with the ladies and nights with the boys. The Great Gildersleeve may have been the first broadcast show to be centered on a single parent balancing child-rearing, work, and a social life, done with taste and genuine wit, often at the expense of Gildersleeve's now slightly understated pomposity. Many of the original episodes were co-written by John Whedon, father of Tom Whedon (who wrote The Golden Girls), and grandfather of Deadwood scripter Zack Whedon and Joss Whedon (creator of Buffy the Vampire Slayer, Firefly and Dr. Horrible's Sing-Along Blog). The key to the show was Peary, whose booming voice and facility with moans, groans, laughs, shudders and inflection was as close to body language and facial suggestion as a voice could get. Peary was so effective, and Gildersleeve became so familiar a character, that he was referenced and satirized periodically in other comedies and in a few cartoons. http://en.wikipedia.org/wiki/The_Great_Gildersleeve
Просмотров: 76526 Remember This